Advances in cancer stromal cells and their association with ovarian cancer therapy
10.3969/j.issn.1007-3969.2016.04.011
- VernacularTitle:癌间质细胞与卵巢癌治疗相关性研究进展
- Author:
Fan LIANG
;
Yaping CHEN
;
Gong YANG
- Publication Type:Journal Article
- Keywords:
Ovarian cancer;
Tumor stroma;
Endothelial cells;
Fibroblasts;
Macrophages;
Targeted therapy
- From:
China Oncology
2016;26(4):351-357
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian cancer bears the highest mortality in gynecologic cancer, and its 5-year survival rate is about 30%. Although 70% to 80% ovarian cancer is epithelial origin, increasing evidence indicates that reciprocal interactions between tumor cells and various types of stromal cells also play important roles in driving ovarian tumor progression and that these stromal cells represent attractive therapeutic targets. This review discusses the biological signiifcance of the cross-talk between ovarian cancer cells and three major types of stromal cells (endothelial cells, ifbroblasts and macrophages) and the development of new-generation therapies that target the ovarian tumor micro-environment.
