The expression level of Mig in chronic hepatitis B patients
10.3969/j.issn.1673-4130.2016.09.002
- VernacularTitle:慢性乙型肝炎患者趋化因子Mig表达水平的研究
- Author:
Liangchun FANG
;
Shihe GUAN
;
Qiang ZHOU
;
Huijuan BI
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
chemotactic factor;
enzyme linked immunosorbent assay
- From:
International Journal of Laboratory Medicine
2016;37(9):1164-1165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression levels of Mig in the patients with chronic hepatitis B .Methods The study pop‐ulation consisted of 88 chronic hepatitis B patients and 53 healthy controls .The ELISA ,RT‐PCR and Western‐blotting were used for analysing the expression levels of Mig in serum ,peripheral blood mononuclear cells and liver tissue of the patients with chronic hepatitis B ,while the immunohistochemistry was applied for analysing the distribution of Mig in liver tissue .Results The expres‐sion of Mig in serum ,peripheral blood mononuclear cells and liver tissue of the chronic hepatitis B patients with HBeAg negative were (247 .03 ± 63 .14)pg/mL ,(0 .95 ± 0 .21) ,(0 .79 ± 0 .23) ,and that in the chronic hepatitis B patients with HBeAg positive were (243 .05 ± 53 .00)pg/mL ,(0 .98 ± 0 .35) ,(0 .74 ± 0 .18) ,which were both significantly higher than those in healthy controls ,the difference was statistically significant(P<0 .05) .Conclusion Increased levels of Mig in the patients with chronic hepatitis B may be related to immune state of patients .
