The changes of urine microalbuminuria and serum C-reactive protein levels in patients with diabetic retinopathy and its significance
10.3969/j.issn.1673-4130.2016.09.015
- VernacularTitle:糖尿病视网膜病变患者尿微量清蛋白与血清C-反应蛋白水平的变化及意义
- Author:
Aiping PAN
;
Yunxia YANG
;
Honglei XU
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
urine microalbuminuria;
C-reactive protein
- From:
International Journal of Laboratory Medicine
2016;37(9):1192-1194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of urine microalbuminuria(UMA) and serum C‐reactive protein(CRP) levels in patients with diabetic retinopathy(DR) and its significance .Methods A total of 152 type 2 diabetes mellitus(T2DM ) patients were included and 40 healthy individuals as normal controls(NC) .T2DM patients were divided into 3 groups ,65 patients with non‐dia‐betic retinopathy(NDR group) ,53 patients with non‐proliferative diabetic retinopathy(NPDR group) and 34 patients with prolifera‐tive diabetic retinopathy(PDR group) .UMA ,CRP and other clinical parameters were detect .Results The level of UMA and CRP increased progressively from NC ,NDR ,NPDR ,to PDR groups ,and there were significant differences among groups(P<0 .05) .The analysis of spearman rank correlation showed that UMA was positively associated with CRP(r=0 .311 ,P<0 .05) .UMA was also positively associated with the duration of diabetes ,fasting blood glucose(FBG) ,low density lipoprotein cholesterol(LDL‐C) ,hemo‐globin A1c(HbA1c) and homeostasis model assessment of insulin resistance(P< 0 .05) ,and CRP was also positively associated with the duration of diabetes ,FBG ,HbA1c and HOMA‐IR(P<0 .05) .Conclusion The development of DR is closely associated with kidney injury ,and chronic inflammation ,hyperglycemia and insulin resistance may be involved in the development and patho‐genesis of DR by interacting the renal function of T2DM patients .
