Comparative Study on Chemical Ingredients and Angiogenesis Effects for Different Compatibility Proportions ofDanggui Buxue Decoction
10.3969/j.issn.1005-5304.2016.06.022
- VernacularTitle:不同配伍比例当归补血汤化学成分及促血管新生作用比较
- Author:
Ruifang XIE
;
Pinglan LIN
;
Ying WANG
;
Xin ZHOU
- Publication Type:Journal Article
- Keywords:
Danggui Buxue Decoction;
chemical components;
zebrafish;
angiogenesis
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(6):83-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study chemical ingredients and angiogenesis effects for different compatibility proportions ofDanggui Buxue Decoction.Methods For chemical components, HPLC was performed to study the ingredients (Ferulic Acid, Calycosin-7-glusosido, Calycosin, Formononetin) inDanggui Buxue Decoction. For angiogenesis effects, transgenosis zebrafish model was incubated with different proportions ofDanggui Buxue Decoction.Results With the raise of Astragali Radix content, the synthetic scores of four ingredients in different compatibility proportions increased. When the Astragali Radix content to Angelicae Sinensis Radix content was 8 to 2 and 5 to 1, the scores were the highest. For zebrafish vascular injury model, vessel recoveries in top three were 5:1, 6:1 and 2:1 (Astragali Radix: Angelicae Sinensis Radix).Conclusion From comprehensive analysis of chemical composition and angiogenesis, the best compatibility ratio of Astragali Radix to Angelicae Sinensis Radix is 5:1.
