Anti-adhesion effect of absorbable biomaterials during tendon reconstruction
10.3969/j.issn.2095-4344.2016.21.021
- VernacularTitle:可吸收生物材料在肌腱损伤重建中的防粘连作用
- Author:
Dong KANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(21):3185-3192
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND:After sports tendon injury, tendon adhesion is the main reason for the failure to repair tendon injury. So, an ideal anti-adhesion material plays an important role in the tendon reconstruction.
OBGECTIVE:To analyze the clinical effect and features of absorbable medical biomaterials in inhibiting tendon adhesion after repair of sports tendon injury.
METHODS:CNKI and Pub Med database were retrieved by the first author using computer to search relevant articles about meniscal repair and tissue engineering technology published from 1988 to 2015. The key words were “tendon repair, tendon adhesion, absorbable biomaterials” in Chinese and English, respectively.
RESULTS AND CONCLUSION:Basic and clinical studies on absorbable anti-adhesion materials have achieved remarkable results. Currently absorbable anti-adhesion materials include hyaluronic acid, polylactic acid, colagen and fibrin glue, which have good biocompatibility and can be absorbed and degradedin vivo. With simple clinical implementation, these materials can completely cover the wound surface. The main mechanisms are as folows: reducing the generation of colagen fibers, isolation barrier, accelerating hemostasis, antisepsis and anti-inflammation, thereby effectively reducing reconstructed tendon adhesion and promoting tendon healing. But they have their limitations: hyaluronic acid has short acting durationin vivoand immunogenicity; polylactic acid eventualy is decomposed into smal molecules that cancause aseptic inflammation; colagen and fibrin glue both have certain shortcomings in biocompatibility and activity.
