The effect ofTanreqing injection combined with conventional western medicine therapy on children with bronchioliti
10.3760/cma.j.issn.1673-4246.2016.06.009
- VernacularTitle:痰热清注射液结合西医常规疗法治疗小儿毛细支气管炎临床研究
- Author:
Zhuxing FENG
;
Xinqi LI
;
Qiaorong LI
- Publication Type:Journal Article
- Keywords:
Bronchioliti;
Tanreqing injection;
Th17 cells;
Treg cells
- From:
International Journal of Traditional Chinese Medicine
2016;38(6):515-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the effect ofTanreqing injection combined with conventional western medicine therapy on children with bronchioliti.Methods A total of 116 children with bronchioliti were enrolled in this study. Children were randomly divided into the control group (n=58) andTanreqing injection observation group (n=58). The control group received continued low flow oxygen, anti-infection treatment, and salbutamol aerosol to relieve asthma. The observation group receivedTanreqing injection based on the intervention of control group. Each group was treated for 7 d. The Th17 and Treg cells were detected by cytometry analysis and the expression of IL-17 and IL-10 were detected by ELISA analysis. The clinical effect of the two groups was compared.Results After treatment, compared with the control group, the Th17 cells (5.91% ± 0.83%vs. 7.23% ± 1.25%,t=2.346) and IL-17 (14.62 ± 3.24 ng/mlvs. 22.52 ± 5.14 ng/ml,t=2.412) decreased significantly, and the Treg cells (7.32% ± 1.24%vs. 5.32% ± 1.03%,t=2.352) and IL-10 (15.84 ± 2.23 ng/mlvs.11.72 ± 2.12 ng/ml,t=2.365) increased significantly in the observation group (P<0.05). The temperature recovery time (t=2.264,P=0.048), disappearance time of coughing (t=2.437,P=3.406), wheezing(t=2.258,P=2.352), pulmonary rales (t=0.032,P=0.034) and hospital duration (t=0.046,P=0.042) in the control group were significantly higher than those in the observation group. The clinical effective rate (94.8%, 55/58) in observation group was higher than that (79.3%, 46/58) in control group (χ2=2.327,P=0.041). ConclusionTanreqing injection can regulate Th17/Treg cell balance, and its curative effect is superior to conventional therapy in children with bronchiolitis.
