To optimize the concentrate process ofDanshen injection by nanofiltration technique

VernacularTitle:基于纳滤分离优势优化丹参注射液的生产浓缩工艺
Author: Cunyu LI ; Yun MA ; Tao CHEN ; Hongyang LI ; Guoping PENG
Publication Type:Journal Article
Keywords: Dan shen zhu she ye; Nanofiltration; Concentrate process; Technology improving (TCD)
From: International Journal of Traditional Chinese Medicine 2016;38(6):543-545
CountryChina
Language:Chinese
Abstract: Objective To optimize the concentrate process ofDanshen injection.Methods The concentration changes of Salvianic acid A sodium, Protocatechuic aldehyde and Salvianolic acid B were selected as indexes to compare mospheric concentrate, vacuum concentrate, nanofiltration concentrate and nanofiltration-vacuum coupling concentrate methods with HPLC. Results Phenolic acid composition changed when atmospheric and vacuum concentrate method were used. Retention rate of three phenolic acids were over 93% after nanofiltration concentration, but the concentration efficiency was limited by solution viscosity. Nanofiltration-vacuum coupling concentrate methods could solve the above problems, meanwhile, retention rate of three phenolic acids were over 91%.Conclusions Nanofiltration technology takes advantage in medicine extraction concentrate with heat sensitive ingredients, and its application prospect in traditional Chinese medicine pharmaceutical industry would be broad.