Pediatric inherited cancer predisposition syndromes and TP53 germ-line mutation
10.3969/j.issn.1000-3606.2016.05.004
- VernacularTitle:儿童遗传性肿瘤易感综合征和TP53基因种系突变
- Author:
Yuejia TANG
;
Yijin GAO
- Publication Type:Journal Article
- Keywords:
hereditary cancer predisposition syndrome;
p53genes;
tumor suppressor protein p53;
Li-Fraumeni syndrome
- From:
Journal of Clinical Pediatrics
2016;34(5):333-337
- CountryChina
- Language:Chinese
-
Abstract:
Pediatric inherited cancer predisposition syndromes are a group of diseases caused by germ-line mutation of cancer related genes. The patients are susceptible to cancers. TP53 germ-line mutation is the most commonly seen mutant gene in cancers that accounts for 20%-30%of all germ-line mutations of inherited cancers. TP53 gene mutation screening could help clinicians to better manage the patients and their family members.
