Role of oxidative stress in molecular pathogenesis of endemic fluorosis
10.3760/cma.j.issn.2095-4255.2016.02.001
- VernacularTitle:氧化应激在地方性氟中毒分子发病机制中的作用
- Author:
Zhizhong GUAN
- Publication Type:Journal Article
- Keywords:
Fluorosis;
Oxidative stress;
Pathogenesis;
Antioxidants
- From:
Chinese Journal of Endemiology
2016;35(2):79-82
- CountryChina
- Language:Chinese
-
Abstract:
Endemic (chronic) fluorosis causes systemic pathological damages,in which the pathogenesis of the disease is complex.Among those relating mechanisms,oxidative stress is a generally accepted theory so far.The comments made in the present paper mainly concern the changes of conventional examinations for oxidative stress,the correlations between oxidative stress and biological membrane lipids,acetylcholine receptors,signal translation systems and apoptosis,and the clinic or experimental investigations on anti-oxidants.It is emphasized that oxidative stress plays an important role in the molecular mechanisms of systemic damages resulted from endemic fluorosis,which may provide theoretical evidence for clinical prevention and treatment,as well as drug development to the disease.
