The diagnostic value analysis on serum total type Ⅰ amino terminal extension of the peptide and vitamin D3 in chronic obstructive pulmonary disease patients suffered from osteoporosis
10.3760/cma.j.issn.1673-4904.2015.12.011
- VernacularTitle:血清总Ⅰ型氨基末端延长肽和维生素D3对慢性阻塞性肺疾病患者罹患骨质疏松诊断价值分析
- Author:
Liyan SHEN
;
Cunzhi LIN
;
Shaoyan ZHANG
;
Lili XU
;
Fei WANG
;
Qing WANG
- Publication Type:Journal Article
- Keywords:
Pulmonary diseases,chronic obstructive;
Osteoporosis;
Cholecalciferol;
Total type Ⅰ amino terminal extension of peptide;
Smoking index
- From:
Chinese Journal of Postgraduates of Medicine
2015;38(12):894-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between osteoporosis and serum total type Ⅰ amino terminal extension of the peptide,vitamin D3 and smoking index in the patients with chronic obstructive pulmonary disease (COPD).Methods One hundred and fifty patients with COPD (test group) and 150 healthy people (control group) were selected.The total type Ⅰ amino terminal extension of the peptide was measured by electrochemical luminescence,and enzyme-linked immunoassay was adopted to determine the vitamin D3.The 150 patients with COPD were divided into slight group (45 cases),moderate group (52 cases) and severe group (53 cases) according to the severity of COPD.In 150 patients with COPD,120 patients with smoking were divided into 3 groups according to smoking index:A group smoking index ＜ 360,36 cases;B group smoking index 360-400,34 cases;and C group smoking index 401-560,50 cases.The levels of serum total type Ⅰ amino terminal extension of the peptide and vitamin D3 were compared and correlation was analyzed.Results The vitamin D3 and the total type Ⅰ amino terminal extension of the peptide levels in test group were significandy lower than those in control group:(35.37 ± 12.11) mg/L vs.(45.88 ± 12.55) mg/L and (38.16 ± 11.12) mg/L vs.(45.23 ± 12.33) mg/L,and there were statistical differences (t =2.74 and 4.64,P＜ 0.01).The levels of vitamin D3 and the total type Ⅰ amino terminal extension of the peptide in slight,moderate and severe group were decreased in turn,and the levels of total type Ⅰ amino terminal extension of the peptide and the vitamin D3 were positively associated with the severity of COPD (r =0.185 and 0.257,P ＜ 0.05).The levels of vitamin D3 and total type Ⅰ amino terminal extension of the peptide in A,B and C group were decreased in turn,and the levels of total type Ⅰ amino terminal extension of the peptide and the vitamin D3 were positively associated with smoking index (r =0.159 and 0.172,P ＜ 0.05).Conclusion COPD patients are easier to suffer from osteoporosis compared with healthy population,and the serum vitamin D3 and total type Ⅰ amino terminal extension of the peptide can forecast the osteoporosis in COPD patients.
