Correlation between microemboli and lipoprotein-associated phospholipase A2 in patients with acute cerebral infarction
10.3760/cma.j.issn.1673-4904.2015.12.006
- VernacularTitle:急性脑梗死患者脑血流中微栓子与脂蛋白相关磷脂酶A2的相关性研究
- Author:
Na LI
;
Linwen LI
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Microemboli;
Lipoprotein-associated phospholipase A2
- From:
Chinese Journal of Postgraduates of Medicine
2015;38(12):877-879
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between microemboli and lipoprotein-associated phospholipase A2 (LP-PLA2) in patients with acute cerebral infarction.Methods One hundred and ninetytwo patients were selected,among whom 112 patients were acute cerebral infarction in internal carotid or middle cerebral arterial area within 48 hours.The microemboli signal (MES) was measured by transcranial Doppler sonography.The patients were divided into MES positive group (42 cases) and MES negative group (70 cases) according the measured method;80 patients without cerebrovascular disease were as control group (they had no the histories of cerebral vascular diseases and internal and external carotid artery stenosis).Theserum LP-PLA2 levels were measured by enzyme linked immunosorbent assay.Results The LP-PLA2 in control group was (20.09 ± 7.27) μ g/L,in MES negative group was (47.70 ± 23.86) μ g/L,and there was statistical difference (P＜0.01).The LP-PLA2 in MES positive group was (59.45 ± 19.51) μg/L,and there was statistical difference compared with control group (P ＜ 0.01),and there was statistical difference compared with MES negative group (P ＜ 0.05).There was positive correlation between hypertension,hyperlipemia,LP-PLA2 and cerebral infarction (P ＜ 0.05).Conclusions LP-PLA2 relates to instability of atherosclerotic plaque.Microemboli and LP-PLA2 levels are risk factors for cerebral infarction.
