The analysis of the changes of high density lipoprotein cholesterol and high sensitivity C reactive protein in coronary heart disease patients combined with type 2 diabetes mellitus
10.3760/cma.j.issn.1673-4904.2015.12.009
- VernacularTitle:高密度脂蛋白胆固醇及高敏C反应蛋白在老年冠心病合并2型糖尿病中的变化意义分析
- Author:
Shan LU
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Diabetes mellitus,type 2;
Cholesterol,HDL;
C reactive protein;
Aged
- From:
Chinese Journal of Postgraduates of Medicine
2015;38(12):886-889
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of the changes of high density lipoprotein cholesterol (HDL-C) and high sensitivity C reactive protein (hs-CRP) in coronary heart disease patients combined with type 2 diabetes mellitus,and analyze the relationship between HDL-C and hs-CRP.Methods Two hundred and ten elder patients were selected.The patients were divided into simple coronary heart disease group (A group,70 cases),coronary heart disease combined with type 2 diabetes mellitus group (B group,71 cases),and simple type 2 diabetes mellitus group (C group,69 cases) according to the pathogenetic condition.Meanwhile 50 healthy controls were selected as control group (D group).The levels of HDL-C and hs-CRP were measured,and correlation analysis used Pearson linear correlation.Results The levels of HDL-C in A,B and C group were significantly lower than those in D group:(1.98 ± 0.47),(0.99 ± 0.31) and (1.27 ± 0.44) mmol/L vs.(2.18 ± 0.42) mmol/L,and there were statistical differences (P ＜ 0.05 or ＜0.01);the level of HDL-C in B group was significantly lower than that in A and C group,and there were statistical differences (P ＜ 0.05).The levels of hs-CRP in A,B,and C group were significantly higher than that in D group:(5.71 ± 1.81),(7.71 ± 2.32) and (4.68 ± 2.09) mg/L vs.(1.60 ± 0.80) mg/L,and there were statistical differences (P＜ 0.01);the level of hs-CRP in B group was significantly higher than that in A and C group,and there were statistical differences (P ＜ 0.05).Correlation analysis results showed that hs-CRP and HDL-C had signficant negative correlation (r =-0.304,P ＜ 0.01),and hs-CRP and LDL-C had signficant positive correlation (r =0.341,P ＜ 0.01),hs-CRP and triacylglycerol (TG) had no correlation (r =0.006,P ＞ 0.05);hs-CRP and fasting plasma glucose (FPG) had signficant positive correlation (r =0.415,P ＜ 0.01),and hs-CRP and glycosylated hemoglobin (HbA1c) had signficant positive correlation (r =0.384,P ＜ 0.01).Conclusions The levels of HDL-C in patients with elder patients with simple coronary heart disease and simple type 2 diabetes mellitus are significantly lower,and the levels of hs-CRP are significantly higher.The level of HDL-C in elder coronary heart disease patients combined with type 2 diabetes mellitus is significantly lower than that in elder patients with simple coronary heart disease and simple type 2 diabetes mellitus,and the level of hs-CRP is significantly higher than that in elder patients with simple coronary heart disease and simple type 2 diabetes mellitus.The level of hs-CRP is HDL-C have signficant negative correlation.
