Application of recombinant human growth hormone in treatment of Prader-Willi syndrome

VernacularTitle:重组人生长激素在Prader-Willi综合征治疗中的应用
Author: Xiaohong CHEN ; Hui YAO
Publication Type:Journal Article
Keywords: Prader-Willi syndrome; Recombinant human growth hormone; Insulin-like growth factor-1; Obesity; Metabolic syndrome
From: Chinese Journal of Applied Clinical Pediatrics 2016;31(8):564-568
CountryChina
Language:Chinese
Abstract: Prader-Willi syndrome is a rare genetic disorder characterized by hypotonia,poor feeding in infancy,hyperphagia with evolving obesity,hypogonadism,decreased adult height,and cognitive and behavioral disabilities.Recombinant human growth hormone (rhGH) has been used in treating Prader-Willi syndrome,and it has achieved good results.Several aspects still need to be concerned,including evaluation before rhGH treatment,age at treatment initiation,dosing,monitoring of potential side effects,tolerability,endpoint,response evaluation,use of adjunct therapies,and issues of consent.