The utility of BTBR mouse model in autism research
10.3760/cma.j.issn.2095-428X.2015.24.021
- VernacularTitle:BTBR小鼠动物模型在孤独症研究中的作用
- Author:
Hongen WEI
;
Fengyun HU
- Publication Type:Journal Article
- Keywords:
Autism;
Animal model;
BTBR mice
- From:
Chinese Journal of Applied Clinical Pediatrics
2015;30(24):1918-1920
- CountryChina
- Language:Chinese
-
Abstract:
Several of the genetic models and environmental risk factor models were used in the animal model study in autism.The BTBR T+ Itpr3tf(BTBR) mice are an inbred strain and have emerged as strong candidates to serve as models of a range of autism-relevant behaviors, showing deficiencies in social behaviors and reduced or unusual ultrasonic vocalizations as well as increased repetitive self-grooming.There are increasing investigations targeted to ameliorating the behavioral phenotypes of autism in BTBR mice.This review briefly summarizes the advance in the research on the BTBR mice model of autism.
