Apoptosis induction and associated factor of Staphylococcus aureus in J774A.1 mouse macrophage cell line.
- Author:
Sang Ho KIM
1
;
Chang Min LEE
;
Soo Jin JEONG
;
Min Ho JEONG
;
Jin Koo KIM
;
Jae Kwan CHA
;
Hyung Sik LEE
;
Young Jin LIM
;
Sang Hwa LEE
Author Information
1. Institute of Medical Science, Dong-A University College of Medicine, Pusan, South Korea.
- Publication Type:Original Article
- MeSH:
Animals;
Apoptosis*;
Bacteria;
Cell Death;
Cell Line*;
DNA;
Host-Parasite Interactions;
Macrophages*;
Mice*;
Phagocytosis;
Staphylococcus aureus*;
Staphylococcus*
- From:Journal of the Korean Society for Microbiology
2000;35(1):87-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Staphylococcus aureus infections are often life-threatening. Relatively little is known about the host response to these infections, in particular, the implication of apoptosis induced by this microorganism. In this study, we have shown that S. aureus was cytotoxic to J774A.1 cell, a murine macrophage cell line. The cell death mediated by S. aureus occurred through apoptosis, as shown by increase in the proportion of fragmented host cell DNA. Although phagocytosis and NO production had important role in the induction of apoptosis, the contact between bacteria and host cells was not essential for this pathway. A certain bacterial product could also induce typical caspase-dependent apoptosis of J774A.1 cell. It is expected that new interpretation may be possible to host-parasite relationship based on these results.
