Clinical curative effect observation on Huatan-Tongfu decoction in curing the heat-phlegm and sthenic-fu syndrome of subarachnoid hemorrhage
10.3760/cma.j.issn.1673-4246.2015.12.007
- VernacularTitle:自拟化痰通腑汤治疗蛛网膜下腔出血痰热腑实证临床研究
- Author:
Jing LV
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Syndrome differentiation classification;
Huatan-Tongfu decoction;
Nimodipine;
Integrated Chinese traditional and western medicine therapy
- From:
International Journal of Traditional Chinese Medicine
2015;37(12):1082-1085
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of Huatan-Tongfu decoction in the treatment of subarachnoid hemorrhage (SAH) with heat-phlegm and sthenic-fu syndrome.Methods The SAH patients met the inclusion criteria were randomly recruited into a control group and a treatment group, 41 patients in each group.The control group was treated with western conventional medicine and sustained administration of nimodipine injection;the treatment group was nasal feeding or oral taking Huatan-Tongfu decoction on the basis of the control group.Both groups were treated for 14 days.On respectively 3, 7, 14 days after treatment the level of subarachnoid hematocele was evaluated with modified Fisher gradehemorrhage, the degree of serum nitric oxide levels was detected with ELISA method, and the clinical efficacy was evaluated according to the neurological impairment score.Results The total effective rate of 3 d (46.3％ vs.36.6％, P=0.006), 7 d (58.5％ vs.43.9％, P=0.000), 14 d (73.2％ vs.58.5％, P=0.000) in the treatment group were better than the control group (P＜0.01).After treatment 7 d (22.93 ± 7.32 μmol/L vs.16.52 ± 5.79 μmol/L, P=0.034), 14 d (27.65 ± 5.06 μmol/L vs.19.54 ± 3.76 μmol/L, P=0.015) serum nitric oxide levels in the treatment group were higher than in the control group (P＜0.05).After treatment, the improved Fisher scoring (1.29 ± 0.23 vs.1.69 ± 0.38, t=5.766) in the treatment group was significantly lower than the control group (P＜0.01).Conclusion Huatan-Tongfu decoction can improve SAH with heat-phlegm and sthenic-fu syndrome, relieve neurological defect function, reduce levels of NO, and improve clinical efficacy.
