Plasmacytoma variant translocation 1 in cancer
10.3760/cma.j.issn.1673-422X.2016.02.017
- VernacularTitle:浆细胞瘤转化迁移基因1在肿瘤中的研究进展
- Author:
Juanfei PENG
;
Shineng ZHANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Plasmacytoma variant translocation 1
- From:
Journal of International Oncology
2016;43(2):141-144
- CountryChina
- Language:Chinese
-
Abstract:
Plasmacytoma variant translocation1 (PVT1) is a very important long nocoding RNA,which located at chromosome 8q24.21 in human beings.Aberrant expression and polymorphism of PVT1 was closely associated with various kinds of cancers such as malignant lymphoma,breast cancer,colorectal cancer,pancreatic cancer,and affected survival and prognosis of cancer patients.This mainly attribute to its interactin with myc,miRNAs and other proteins,and also gene polymorphism.Further study of PVT1 is expected to provide a new target for the diagnosis and treatment of cancer.
