Voltage-gated potassium channel Kv1.5 and cancer
10.3760/cma.j.issn.1673-422X.2016.02.014
- VernacularTitle:电压门控钾离子通道Kv1.5与肿瘤
- Author:
Zhida CHEN
;
Wenrong ZENG
;
Bin LIN
;
Xinyu WU
;
Jin WU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Antineoplastic agents;
Kv1.5 potassium channels
- From:
Journal of International Oncology
2016;43(2):130-132
- CountryChina
- Language:Chinese
-
Abstract:
The voltage-gated potassium channels Kvl.5 is widely expressed in the plasma membranes of numerous tumor cells and it can contribute to a variety of cellular functions such as proliferation,ap optosis,and cell cycle.Several types of antineoplastic drugs can change the expression of Kv1.5 and then affect the biological processes.Kv1.5 is identified as a novel target for therapy in human cancer.The researches of Kv1.5 will contribute to gain a further understanding of the molecular mechanism of tumor and provide therapeutic opportunity for the prevention and treatment of cancer.
