Role and regulatory mechanism of microRNA-449 in cancer
10.3760/cma.j.issn.1673-422X.2016.02.008
- VernacularTitle:微小RNA-449在肿瘤中的作用及其调控机制
- Author:
Xiaoli WANG
;
Yongchao CHANG
;
Gang HU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Gene regulatory networks;
microRNA-449
- From:
Journal of International Oncology
2016;43(2):110-112
- CountryChina
- Language:Chinese
-
Abstract:
More than 50％ microRNAs (miRNAs) are located in tumor-associated genome of amplification region or fragile site,which may also act as oncogenes or tumor suppressor gene (TSG).Recently,researches show that the expression of miR-449 is lower in human gastric,lung and ovarian cancer,and may act as TSG.The abnormal expression of miR-449 plays a pivotal role in carcinogenesis and progression,and elucidating its function and regulatory,mechanism can provide valuable diagnostic,prognostic biomarker for cancer management.
