Expression and functional mechanism of high mobility group A2 in neoplasm
10.3760/cma.j.issn.1673-422X.2016.02.007
- VernacularTitle:高迁移率蛋白A2在肿瘤中的表达及作用机制
- Author:
Qing LI
;
Ying LU
;
Chunying ZHANG
;
Jun MAO
;
Lianhong LI
- Publication Type:Journal Article
- Keywords:
HMGA2 protein;
Neoplasms;
Gene expression;
Functional mechanism
- From:
Journal of International Oncology
2016;43(2):106-109
- CountryChina
- Language:Chinese
-
Abstract:
The high mobility group A2 (HMGA2),one of non-histone chromatin protein,can specificly bind to AT-rich DNA sequences by its AT-hook and work as oncofetal gene and architectural transcription factor.HMGA2 expresses in almost all kinds of malignant neoplasms,which is closely related to the formation,development and poor prognosis of the neoplasms.HMGA2 plays a very important role in every biological process including cell proliferation,cell cycle,stem cell self-renewal,epithelial-mesenchymal transition and DNA damage repair.It is of great significance to study the effect and mechanism of HMGA2 in neoplasms.
