Ring finger protein 43 gene and its function in digestive system cancer
10.3760/cma.j.issn.1673-422X.2016.01.016
- VernacularTitle:环指蛋白43基因及其在消化系统肿瘤中的功能
- Author:
Wangwang QIU
;
Zhili YANG
;
Qi ZHENG
- Publication Type:Journal Article
- Keywords:
Gene expression regulation;
Digestive system neoplasms;
Gene,tumor suppressor;
Ring finger protein 43
- From:
Journal of International Oncology
2016;43(1):56-59
- CountryChina
- Language:Chinese
-
Abstract:
Ring finger protein 43 (RNF43) is a ring-type E3 ubiquitin ligase.As a negative regulater of Wnt signaling pathway, RNF43 has an important anti-tumor effect.The mutation of RNF43 may cause abnormal activation of Wnt signaling pathway, and then promote invasion, metastasis and proliferation of tumor cell.In addition, the act of RNF43 protein in the Wnt signal pathway is expected to be a molecular target in the therapy of cancer.In recent years, with the gradual deepening of related research, the molecular structure of RNF43 protein and its mechanism of action with the Wnt pathway-related proteins have been gradually clear.In clinical, RNF43 protein analogs and related vaccine also show the important position in the therapy of cancer.
