Molecular targeted therapy for non-small cell lung cancer and drug resistance
10.3760/cma.j.issn.1673-422X.2016.01.013
- VernacularTitle:非小细胞肺癌分子靶向治疗及其耐药
- Author:
Yu ZHANG
;
Jianguo ZHOU
;
Hu MA
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Mutation;
Receptor,epidermal growth factor;
Drug resistance,neoplasm;
Molecular targeted therapy
- From:
Journal of International Oncology
2016;43(1):45-48
- CountryChina
- Language:Chinese
-
Abstract:
Gefitinib and erlotinib play important roles, which as the representative of the epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer (NSCLC).However, preclinical and clinical studies find that many patients exist primary or acquired drug resistance to this drug, which limits the use of molecular targeted therapy drugs.At present, there are many studies focus on delaying or reversing drug resistance and developing new targets, which provide more potential for the molecular targeted therapy of NSCIC.
