Roles of MTH1 gene in the occurrence and treatment of cancers
10.3760/cma.j.issn.1673-422X.2016.01.007
- VernacularTitle:MTH1基因在肿瘤发生及治疗中的作用
- Author:
Xuwen GUAN
;
Dingzhi HUANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Reactive oxygen species;
Targeted therapy
- From:
Journal of International Oncology
2016;43(1):26-28
- CountryChina
- Language:Chinese
-
Abstract:
MTH1 protein can mitigate DNA damage which caused by reactive oxygen species through hydrolyzing oxidized deoxy-ribonucleoside triphosphate.MTH1 is highly expressed in various cancers, so as to maintain the viability of cancer cells.MTH1 is closely related to tumor associated genes such as microRNA,RAS gene and p53 gene.Moreover, MTH1 inhibitors can selectively suppress the proliferation of cancers,which is a potential new target in tumor therapy.
