Signaling pathways of epithelial-mesenchymal transition in colon cancer
10.3760/cma.j.issn.1673-422X.2016.05.017
- VernacularTitle:结肠癌上皮间质转化信号通路机制研究
- Author:
Xiaoqing LI
;
Yuanfei LI
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Epithelial-mesenchymal transition
- From:
Journal of International Oncology
2016;43(5):385-386
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition (EMT) plays a critical role in the carcinogenesis of colon cancer,and promotes the tumor invasion and metastasis.Studies have shown several signals are involved including transforming growth factor-β (TGF-β),Wnt/β-catein,Notch,nuclear factor-κB (NF-κB) and PI3K/Akt signal pathway.It is important to elucidate EMT-related signal pathway thereby providing new insights into possible therapeutic interventions of colon cancer.
