Research progress of CTHRC1 in gastrointestinal cancers

VernacularTitle:CTHRC1在消化系统肿瘤中的研究进展
Author: Yan WANG ; Lu WANG ; Jiangzhou FENG ; Deng LI
Publication Type:Journal Article
Keywords: Digestive system neoplasms; Genes; Collagen triple helix repeat containing 1
From: Journal of International Oncology 2016;43(5):382-384
CountryChina
Language:Chinese
Abstract: Collagen triple helix repeat containing 1 (CTHRC1) can repair the injured vessel by limiting the deposition of collagen and promoting cell migration.CTHRC1 is mainly regulated by Wnt-PCP signaling pathway,transforming growth factor (TGF)-bone morphogenetic protein (BMP) signaling pathway and extracellular signal-regulated kinase (ERK)-matrix metalloproteinase 9 (MMP9) signaling pathway.Recent studies have identified that CTHRC1 is aberrantly expressed in gastrointestinal cancers and associated with the occurring and development of cancers.