Expression and clinical significance of RNA-binding protein Musashi1 in colorectal cancer
10.3760/cma.j.issn.1673-422X.2016.03.018
- VernacularTitle:RNA结合蛋白Musashi1在结直肠癌中的表达及临床意义
- Author:
Boyue DING
;
Chun HAN
;
Chao GAO
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
RNA-binding proteins;
Musashi1
- From:
Journal of International Oncology
2016;43(3):226-228
- CountryChina
- Language:Chinese
-
Abstract:
Musashi1 (Msi1) is an evolutionary conservative RNA-binding protein (RBP),and it is a stem marker in a variety of organizations,including intestinal,neural system.Msi1 maintains the balance between self-renewal and differentiation.Recently,many researchers report that Msi1 is overexpressed in many types of tumors,especially in colorectal neoplasms,participating in the regulation of cell cycle,proliferation,apoptosis and so on.Msi1 becomes a key regulator of many cancers,which is expected to turn into a new target for cancer therapy.
