Discoidin domain receptor 2 and its expression and role in tumor
10.3760/cma.j.issn.1673-422X.2016.02.013
- VernacularTitle:盘状结构域受体2及其在肿瘤中的表达和作用
- Author:
Lei WANG
;
Dongming LIU
- Publication Type:Journal Article
- Keywords:
Collagen;
Neoplasms;
Discoidin domain receptor 2
- From:
Journal of International Oncology
2016;43(2):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase (RTK) that can be activated by fibrillar collagens (Ⅰ-Ⅲ,X).Recently researchers show that the DDR2 is expressed differently in many cancers,which suggests DDR2 is probably correlated with tumorigenesis and cancer development,and it may become a promising cancer therapeutic target.
