Review research: animal models for colorectal carcinoma liver metastases in rodents
10.3760/cma.j.issn.1673-4203.2016.02.018
- VernacularTitle:结直肠癌肝转移的啮齿动物模型建立的研究进展
- Author:
Hairui WU
;
Jie YIN
;
Jin WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Liver metastases;
Models,animal;
Review
- From:
International Journal of Surgery
2016;43(2):133-135
- CountryChina
- Language:Chinese
-
Abstract:
About 50％ to 60％ of the stage Ⅱ-Ⅲ colorectal carcinoma patient suffer from liver metastases.Recently,there is a research hotspot on how to improve the prognosis of the colorectal carcinoma liver metastases (CRLM) patient.It can elucidate the way how the carcinoma cells transfer from the original tumor to the liver,through establishing a CRLM animal model.An ideal CRLM animal model should perfectly mimic the total procedure of the metastases pathway,including the change of the cytology behavior and the development of the tumor biology.Besides,the model should be practical,tumor-predictable and accord with the ethical consideration.Until now,there is not an ideal CRLM animal model can perfectly match those conditions.This review goes through the advantages and disadvantages of different CRLM animal model methods used for research.
