Research progress of TGIF in related signaling pathways and tumours
10.3760/cma.j.issn.1673-4203.2016.02.017
- VernacularTitle:TGIF蛋白与相关信号通路及肿瘤的研究进展
- Author:
Zhe FU
;
Jianwen YE
;
Wenlong ZHAI
- Publication Type:Journal Article
- Keywords:
TGIF;
Signaling pathway;
Neoplasms;
Review;
Gene expression regulation
- From:
International Journal of Surgery
2016;43(2):128-132
- CountryChina
- Language:Chinese
-
Abstract:
As a nuclear transcription repressor,the functions of TGIF are complicated,not only represses target genes expression directly,but also takes part in the regulation of multiple important cellular signaling pathways,which are associated with the differentiation of cells and tissues,inflammation,metabolism and tumors.In past few years,more and more studies on the role of TGIF in tumors suggest TGIF may be a new therapy target in the diagnosis and treatment of tumours.This article mainly reviews the research progress of TGIF in some signaling pathways like TGF-β,MAPK,PI3K/AKT,and tumours like hepatocellular carcinoma,lung carcinoma and urinary tract urothelial carcinoma.
