Recent research of the disseminated tumor cells in breast cancer
10.3760/cma.j.issn.1673-4203.2015.12.020
- VernacularTitle:乳腺癌骨髓播散肿瘤细胞的研究进展
- Author:
Zhenghui WANG
;
Shui WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Micrometastasis;
Disseminated tumor cell;
Chemotherapy
- From:
International Journal of Surgery
2015;42(12):855-858
- CountryChina
- Language:Chinese
-
Abstract:
The distant metastases is the major cause of death in patients with breast cancer.Metastasis of tumor cells is defined to be a series process including tumor cells shedding from the primary lesion,intruding and circulating in blood vessels,implantation into distant organs and developing into metastasis lesion,only complete the series process can eventually form a distant metastasis.Micrometastasis reters to exist in lymph nodes,peripheral blood and bone marrow,yet conventional testing method usually does not reveal it,the presence of tumor cells in blood called circulating tumor cells,and the tumor cells in bone marrow called disseminated tumor cells.In order to predict and prevent tumor spreading and acquire therapeutic strategy,many attempts are being made to detect small numbers of tumor cells that have shed from the primary lesions.This article presents the techniques used for disseminated tumor cells detection,clinical relevance and biological questions for the recent a few years.
