Advances of MicroRNA in epithelial-mesenchymal transition of gastric cancer
10.3760/cma.j.issn.1673-4203.2016.02.020
- VernacularTitle:MicroRNA在胃癌上皮-间质转化中的研究进展
- Author:
Heihei LI
;
Jiansheng LIU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Epithelial-mesenchymal transition;
MicroRNAs;
Neoplams metastasis
- From:
International Journal of Surgery
2016;43(2):139-144
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition is not only involved in generating normal embryonic development of organs and tissues,but also helps to improve cancer cell invasion and metastasis.When epithelial-nesenchymal is stimulated,cell-cell adhesion and cell polarity are disrupted by disappearance of adhesion molecules such as Ecadherin,resulting in the acquisition of a mesenchymal phenotype.Consequently,cells which have acquired mesenchymal function activate the migratory and invasion capability in cancer.Studies have shown that part of the transcription factors,growth factors and signaling pathways involved in epithelial-nesenchymal process,and miRNA may participates in the proliferation,apoptosis,invasion and metastasis of gastric cancer cells by regulating oncogenes or tumor suppressor genes,which also relates to the regulation of epithelial-nesenchymal.This article will be reviewed in recent years specific miRNA regulatory mechanisms of gastric cancer epithelial-nesenchymal.
