Research progress of microRNA and its effect on transplantation tolerance
10.3760/cma.j.issn.1673-4203.2016.01.019
- VernacularTitle:微小RNA与移植免疫的研究进展
- Author:
Haibo YOU
;
Hao WU
;
Jianping GONG
;
Xuhong LI
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Cell development;
Organ transplantation;
Immune tolerance
- From:
International Journal of Surgery
2016;43(1):61-66
- CountryChina
- Language:Chinese
-
Abstract:
microRNAs combined with specific mRNAs are 19-25 nucleotide-long small-molecule RNA that mediate sequence-dependent post-transcriptional gene expression.Accumulating evidences indicate that microRNAs target critical signal transduction molecules of immune system,and involve in regulation of immune tolerance.Recently,microRNAs have been a potential biomarker,and are widely useded in diagnosis and prognosis of cancer,infectious disease,autoimmune disease,and transplantation.If we can further identify regulatory mechanism of microRNAs and their target genes,which makes possible the successful induction of immune tolerance and exert a huge push on organ transplantation.
