Aberrant methylation reactions in tumor tissues
10.3760/cma.j.issn.1673-4203.2016.01.018
- VernacularTitle:肿瘤组织中的异常甲基化反应
- Author:
Mintuo WANG
;
Zhigang LIU
;
Shenglin CHEN
;
Xiaoyi WANG
;
Lixia SUN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Methionine adenosyltransferase;
S-adenosylmethionine
- From:
International Journal of Surgery
2016;43(1):57-61
- CountryChina
- Language:Chinese
-
Abstract:
The threat of cancer to human being' s health is definite.In order to find more effective cures,experts has always taking the mechanism of tumorigenesis as a research foucus and hot spot.As everyone knows,the basic biological behaviors of malignant cells have changed a lot,such as cell proliferation,apoptosis,and so on,and the causes are related to the aberrant methylation reaction occurred in these cells.Researchers have found out that DNA methylation in tumor tissues were obviously different from that in normal tissues,with the charateristics of extensive hypomethylation and localized hypermethylation.To identify the effect of abnormal methylation reaction in the evolution and progression of tumor,this article is aiming to overview those previously researches about the abnormal methylation reaction in tumor cell and its effect on cell growth.
