Biomaterial implantation associted infection and related gene regulation of biofilm formation by Staphylococcus epidermidis
10.3760/cma.j.issn.1673-4181.2016.01.009
- VernacularTitle:生物材料植入感染与表皮葡萄球菌生物膜形成的相关基因调控
- Author:
Liangting QIU
;
Lianhua YE
;
Yunchao HUANG
- Publication Type:Journal Article
- Keywords:
Staphylococcus epidermidis;
Biofilm;
ica operon;
agr gene;
Biomaterial
- From:
International Journal of Biomedical Engineering
2016;39(1):37-42
- CountryChina
- Language:Chinese
-
Abstract:
Staphylococcus epidermidis is a commensal bacteria which inhabits on the surface of human skin and mucous membrane.It has been demonstrated that staphylococcus epidermidis is a major opportunistic pathogen that can cause clinical biomaterial related infection and plays an important role in biomaterial implantation associated infections.The main pathogenic factor is the formation of the bacterial biofilm on surface of medical biomaterial.The formation of bacterial biofilm can resist the defense reaction and antibiotic treatment effectively so that leading to the biomaterial implantation associated infection which is difficult to cure thoroughly,and make the infections become chronic,persistent and repetitive.Nowadays,the infections caused by Staphylococcus epidermidis have caused high clinical mortality.Staphylococcus epidermidis biofilm formation,the regulations of intercellular adhesion gene (ica) operon and accessory gene regulator (agr) gene on the formation of biofilm and their functions in clinical biomaterial related infections are reviewed in this article.
