Function and clinical applications of bone morphogenetic proteins in bone repair
10.3760/cma.j.issn.1673-4181.2015.06.013
- VernacularTitle:骨形态发生蛋白在骨修复中的作用及临床应用进展
- Author:
Yan YAN
;
Xiaoli LIAN
;
Yanni LI
;
Huiru ZOU
- Publication Type:Journal Article
- Keywords:
Bone morphogenetic proteins;
Osteogenic induction;
Bone repair;
Clinical application
- From:
International Journal of Biomedical Engineering
2015;38(6):374-378
- CountryChina
- Language:Chinese
-
Abstract:
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily, acting as important regulators in embryogenesis and bone and cartilage formation and repair.The complexity of BMPs action has early been unveiled by generous cell and molecular biology approaches and transgenic animal studies.Genetic engineering allows for the mass production of BMPs for clinical use of bone repair, but the desirable scaffold material is also needed to ensure controlled release and maximum biological activity of BMPs at the surgical site.Currently, BMP-2 and BMP-7 have been approved by United States Food and Drug Administration for clinical therapy in long bone fracture, spinal fusion and oral and maxillofacial surgery.The results are satisfactory, but the side effects have been also widely concerned.The functions and clinical applications of BMPs in bon repair are reviewed.
