Correlation between serum C-reactive protein level and carotid atherosclerotic plaque calcification in patients with ischemic stroke or transient ischemic attack
10.3760/cma.j.issn.1673-4165.2015.11.003
- VernacularTitle:血清C反应蛋白水平与缺血性卒中或短暂性脑缺血发作患者颈动脉粥样硬化斑块钙化的相关性
- Author:
Haixia ZHANG
;
Xiangliang CHEN
;
Lulu XIAO
;
Ruidong YE
;
Xinfeng LIU
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Ischemic Attack,Transient;
Carotid Artery Diseases;
C-Reactive Protein;
Calcinosis;
Plaque,Atherosclerotic;
Tomography,X-Ray Computed;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2015;23(11):820-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum C-reactive protein (CRP) level and carotid atherosclerotic plaque calcification in patients with ischemic stroke or transient ischemic attack (TIA).Methods The patients with non-cardiogenic ischemic stroke or TIA in anterior circulation performed head and neck vascular CTA at 1-6 months from the time of onset were enrolled prospectively.The demographic and clinical data were collected and serum CRP levels were detected.Univariate and multivariate logistic regression analyses were used to determine the correlation between the serum CRP level and the carotid atherosclerotic plaque calcification.Results A total of 165 patients were enrolled.Their age was 62.4± 10.6years,male patients accotnted for 66.7％;113 patients (68.5％)had carotid atherosclerotic plaque calcification (calcification group),52 (31.5％) did not have carotid atherosclerotic plaque calcification (non-calcification group).The age of the calcification group (median,interquartlle;66 [58-73] years vs.58 [51-66] years;Z=-3.738,P＜0.001) and CRP levels (1.9 [0.5-3.8] mg/L vs.0.0 [0.0-2.2] mg/L;Z =-4.126,P ＜ 0.001) were significantly higher than those of the non-calcification group.There were no significant differences in other baseline clinical data between the two groups.Multivariate logistic regression analysis showed that age (odds ratio 1.063,95％ confidence interval 1.024-1.104;P =0.001) and CRP levels (odds ratio 1.209,95％ confidence interval 1.030-1.419;P=0.020) were still significantly correlated with the plaque calcification after adjusting for other confounding factors.Conclucions Carotid plaque calcification was correlated with older age and increased serum CRP level in patients with ischemic stroke or TIA.
