Observation on the effect of preoperative radiotherapy on the local advanced middle and low rectal cancer
10.3760/cma.j.issn.1006-9801.2015.12.005
- VernacularTitle:局部中晚期中低位直肠癌术前放疗效果观察
- Author:
Xiaoyun TIAN
;
Xinliang ZHANG
;
Chenglong HAN
;
Bin ZHOU
;
Kai JIANG
;
Qun ZHANG
;
Yuanyuan CHEN
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Radiotherapy;
Colorectal surgery
- From:
Cancer Research and Clinic
2015;27(12):810-813
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the treatment efficacy and radiotherapy side effects of the preoperative long-course radiochemotherapy and preoperative short-course radiotherapy.Methods 64 patients with local advanced middle and low rectal cancer who got the treatment from April 2004 to April 2010 were analyzed retrospectively.40 patients got the preoperative long-course radiochemotherapy under the dose of DT 45-50 Gy/25 F,1.8-2.0 Gy/F,5 F/W,combining with the synchronous capecitabine chemotherapy (1 650 mg/m2,2 F/d,d1-14/d21-35),and accepted operation 4-6 weeks after the radiotherapy.The rest 24 patients underwent the preoperative short-course radiotherapy under the dose of DT 25 Gy/5 F,5 Gy/F,5 F/W,and got the operation in 2 weeks after the radiotherapy.Results The radical and anus reservation rates in preoperative long-course radiochemotherapy group [85.0 ％ (34/40),65.0 ％ (26/40)] were higher than those in preoperative short-course radiotherapy group [58.3 ％ (14/24),33.3 ％ (8/24)] (x2 =5.689,P =0.019;x2 =6.040,P =0.041).There were no significant differences between the two groups on the index of remission rates,radiation injury,surgical complications,and overall survival rate of 1,3,5 years (all P ＞ 0.05).Conclusions The remission rate and overall survival time between the preoperative long-course radiochemotherapy group and preoperative short-course radiotherapy have no significant difference.But the preoperative long-course radiochemotherapy may improve the anus reservation rate and the radical resection rate,without increasing the radiation injury and surgical complications.
