Twist and Shout: A Clinical and Experimental Review of Testicular Torsion.
10.4111/kju.2009.50.12.1159
- Author:
Riyad T ELLATI
1
;
Parviz K KAVOUSSI
;
Terry T TURNER
;
Jeffrey J LYSIAK
Author Information
1. Department of Urology, University of Virginia Health System, USA. jl6n@virginia.edu
- Publication Type:Review
- Keywords:
Testis;
Testicular torsion;
Ischemia;
Reperfusion;
Apoptosis
- MeSH:
Adult;
Apoptosis;
Emergencies;
Humans;
Incidence;
Infertility;
Ischemia;
Male;
Reperfusion;
Reperfusion Injury;
Spermatic Cord;
Spermatic Cord Torsion;
Testis
- From:Korean Journal of Urology
2009;50(12):1159-1167
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This review addresses different aspects of testicular torsion from the clinical perspective as well as the basic cellular and molecular events responsible for the post-torsion testicular changes and pathology, including tissue ischemia-reperfusion injury. MATERIALS AND METHODS: A review of all published literature on testicular torsion was performed by use of two search engines. RESULTS: Testicular torsion, or more correctly termed torsion of the spermatic cord, is a surgical emergency in order to salvage the testis. Its incidence is approximately 1 in 4,000 per annum. Testicular torsion must be treated promptly to avoid loss of the ipsilateral testis; however, even with torsion repair and gross testicular salvage, significant injury may still occur. CONCLUSIONS: The cellular and molecular mechanisms leading to ischemia-reperfusion injury are incompletely understood, and adjuncts to surgical treatment have received little attention. Understanding the cellular and molecular effects is important because 25% of males with a history of torsion may experience adult infertility. This review emphasizes current knowledge of basic science results and clinical outcomes of testicular torsion.
