Meta-analysis of traditional Chinese medicine in the treatment of skin rash caused by epidermal growth factor receptor tyrosine kinase inhibitor
10.3760/cma.j.issn.1006-9801.2015.12.012
- VernacularTitle:中药治疗表皮生长因子受体酪氨酸激酶抑制剂相关皮疹的Meta分析
- Author:
Chuang CHEN
;
Xiugai WANG
;
Zhenchang LIU
;
Yu ZHANG
- Publication Type:Journal Article
- Keywords:
Drugs,chinese herbal;
Epidermal growth factor receptor tyrosine kinase inhibitor;
Exanthema;
Meta-analysis
- From:
Cancer Research and Clinic
2015;27(12):835-837
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of traditional Chinese medicine in the treatment of skin rash caused by epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).Methods The clinical randomized controlled trials of traditional Chinese medicine in the treatment of EGFR-TKI-induced skin rash which published in domestic journals were selected.The quality assessment of included literature was made by Jadad score,RevMan 5.2 software was used to make Meta-analysis.Results A total of 6 studies met the inclusion criteria,the 6 studies included 248 patients,133 cases in the treatment group,115 cases in the control group.All patients were 30 to 75 years old.Compared with the control group,the combined OR value of the clinical efficacy of traditional Chinese medicine in the treatment of EGFR-TKIinduced rash was 7.51,with 95 ％ confidence interval 4.46-12.65.Conclusions Meta-analysis shows that the clinical efficacy of traditional Chinese medicine in the treatment of EGFR-TKI-induced skin rash is better than Western medicine,and no adverse reactions.It can be widely used in clinical practice.
