Analysis of chromosome karyotypes in 80 patients with M2 subtype acute myeloid leukemia in Xinjiang Uygur Autonomous Region
10.3760/cma.j.issn.1006-9801.2015.12.008
- VernacularTitle:新疆维吾尔自治区急性髓系白血病M2亚型患者80例染色体核型分析
- Author:
Yueyue ZHANG
;
Hong LIU
;
Xiaomin WANG
- Publication Type:Journal Article
- Keywords:
Leukemia;
Karyotyping
- From:
Cancer Research and Clinic
2015;27(12):820-822
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the chromosome abnormality characteristics and ethnic differences in patients with M2 subtype acute myeloid leukemia (AML-M2) in Xinjiang Uygur Autonomous Region.Methods The chromosome karyotypes of 80 cases of AML-M2 were detected by using 24 hours short-term culture method and R banding technique.The chromosome abnormality characteristics and ethnic differences were analyzed.Results In 80 patients,48.75 % (39/80) patients had abnormal chromosome karyotype,with t(8;21) abnormaled in 48.71% (19/39),including pure t(8;21) [15.38 % (6/39)] and t(8;21) with other chromosomal abnormalities [33.3 % (13/39)],witch majority with t(8;21) and lack of sex chromosome (-X or -Y) [23.08 % (9/39)].51.28 % (20/39) patients with the exception of t(8;21) chromosomal abnormalities.The differences of abnormal chromosome karyotype in Han and Uygur patients were statistically significant [62.50 % (25/40) vs 35.00 % (14/40),x2 =16.66,P < 0.01].Conclusion The chromosome karyotype characteristics of Han and Uygur M2 patients exist differences.