Recent progress in immunomodulatory mechanisms of mesenchymal stem cells in diabetic retinopathy
10.3760/cma.j.issn.1005-1015.2016.02.028
- VernacularTitle:间充质干细胞对糖尿病视网膜病变炎症反应调节作用的研究进展
- Author:
Wei ZHANG
;
Song CHEN
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy/physiopathology;
Mesenchymal stem cells;
T-lymphocytes,regulatory;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2016;32(2):221-224
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is a common cause of blindness,its occurrence and development are the synergic results of multiple factors.Current studies suggest that inflammation and inflammatory factor has an important role in the pathogenesis of DR.The occurrence and development of DR are closely related with interleukins,intercellular adhesion molecules,hasten factors,tumor necrosis factor,C-reactive protein etc.Mesenchymal stem cells (MSCs) are pluripotent cells derived from the mesoderm and have multiple differentiation potentials,and anti-inflammatory and immunosuppressive function.Recent studies shown that MSCs transplantation can protect damaged retina by inflammatory regulation,which become a new research direction for DR treatment.
