The status and progress of relationship between macrophages polarization and choroidal neovascularization
10.3760/cma.j.issn.1005-1015.2016.01.027
- VernacularTitle:巨噬细胞极化与脉络膜新生血管形成的相关性研究现状与进展
- Author:
Pengfei ZHANG
;
Xiaodong SUN
- Publication Type:Journal Article
- Keywords:
Choroidal neovascularization/etiology;
Macrophages;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2016;32(1):96-99
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are major effecter cells of nonspecific immune response,the polarization of which plays a great role in inflammation,repairing and angiogenesis.According to functional phenotypes,macrophages can be polarized to classically activated type (M1),which could promote angiogenesis,and alternatively activated type (M2),which could inhibit angiogenesis.The proportion of M1/M2 could modulate the growth of choroidal neovascularization (CNV).Under the conditions of aging and injury within the retina,macrophages may polarize to M2,which could generate several proangiogenic factors,initiating and promoting the formation of angiogenesis and fibrous scar.Therefore,regulation of macrophage polarization is expected to inhibit angiogenesis and provide new insight for treatment of CNV.
