Epigenetics of diabetic retinopathy
10.3760/cma.j.issn.1005-1015.2016.02.027
- VernacularTitle:糖尿病视网膜病变表观遗传学研究现状与进展
- Author:
Henan LIU
;
Xun LI
;
Yan LU
;
Xiaolong CHEN
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy/genetics;
Epigenesis,genetic;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2016;32(2):218-221
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetic mechanisms influence gene expression and function without modification of the base sequence of DNA and may generate a genetic phenotype.Epigenetic modifications include DNA methylation,histone modifications,and deployment of noncoding RNA.There is growing evidence that epigenetic mechanisms could play a crucial role in the development of diabetic retinopathy (DR).Molecular biological methods which could maintain mitochondrial homeostasis through the regulation of epigenetic mechanisms may prevent the development of DR.Epigenetic-related treatment modalities will become the new direction of targeted therapy for DR.
