P2X7 receptor and relationship with the death of retinal neurons
10.3760/cma.j.issn.1005-1015.2016.01.030
- VernacularTitle:P2X7受体与视网膜神经元细胞死亡相关性研究现状与进展
- Author:
Xieyi YAO
;
Xun XU
- Publication Type:Journal Article
- Keywords:
Retinal Neurons/cytology;
Cell death;
Receptors,purinergic P2X7;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2016;32(1):108-110
- CountryChina
- Language:Chinese
-
Abstract:
Retinal neuronal cells are crucial in the formation of vision.Injury or death of these cells may lead to irreversible damage to visual function due to their low regenerative capacity.The P2X7 receptor is a trimeric adenosine triphosphate (ATP)-gated cation channel.Recent studies have shown that P2X7 receptor plays a role in retinal neuronal death.In a series of animal models,when exposed to conditions of hypoxia or ischemia,elevated ocular pressure,trauma and exogenous agonists,P2X7 receptor activated by extracellular ATP can cause death of retinal neuronal cells such as retinal ganglion cells and photoreceptor cells through direct or indirect pathways.Blocking the expression and function of P2X7 receptor by its specific antagonist and gene knocking-out,the loss of retinal neuronal cells is significantly attenuated.P2X7 receptor may become a potential novel neuroprotective target for diseases related to the loss of retinal neurons.
