Dysregulation and activation of immune system in age-related macular degeneration pathogenesis
10.3760/cma.j.issn.1005-1015.2016.01.028
- VernacularTitle:免疫活化和调节异常在老年性黄斑变性发病中的作用研究进展
- Author:
Yingxue MA
;
Song CHEN
- Publication Type:Journal Article
- Keywords:
Macular degeneration/etiology;
Immunocompetence;
Immunomodulation;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2016;32(1):100-103
- CountryChina
- Language:Chinese
-
Abstract:
Dysregulation and activation of immune processes are important in age-related macular degeneration (AMD) pathogenesis.The single nucleotide polymorphism of complement factor H is widely recognized as a risk factor to AMD.Over-activation of nod-like receptor3 and polymorphism of Toll-Like Receptor 3 also associated with AMD.Except for innate immune processes,adaptive immunity also play a critical role in AMD,a growing body of evidence supports that auto-antibodies and T cells are related with AMD.Additionally A2E and lipid oxidation byproducts might also have a role in AMD pathogenesis.
