Progresses of cell-based therapy and tissue engineering in the treatment of age-related macular degeneration

VernacularTitle:老年性黄斑变性的细胞疗法及组织工程的研究现状与进展
Author: Bing SHAO ; Di CHEN ; Hanyi MIN
Publication Type:Journal Article
Keywords: Macular degeneration/therapy; Tissue therapy; Tissue engineering; Review
From: Chinese Journal of Ocular Fundus Diseases 2016;32(1):88-91
CountryChina
Language:Chinese
Abstract: Age-related macular degeneration (AMD) has become one of the leading causes of irreversible blindness worldwide.With the advancement of stem cell technology,tissue engineering and biomaterials,cell-based therapy has been inspiring for many degenerative diseases.For its unique advantages,AMD has become one of the most promising fields for cell-based therapy,which involve retinal pigment epithelium(RPE)cells,induced differentiation of neural retina cells and related cytokine regulations.RPE cells can be derived from human embryonic stem cells (hESC) or Induced pluripotent stem cells (iPS).Recently hESC-derived RPE cells have been applied to patients with dry AMD with initial success in clinical trials.In terms of tissue engineering,studies are focused on factors affecting the long-term survival of transplanted cells,including tissue scaffolds,soluble hybrid materials and scaffold anchoring.This article briefly reviews the RPE differentiation,neural retina differentiation and related cytokines of cell-based therapy and scaffolds,materials,and cell-scaffolds interactions of tissue engineering in AMD treatment.