Understanding of progress and challenges in elucidating the susceptibility genes of diabetic retinopathy: improving research quality of susceptibility genes of diabetic retinopathy
10.3760/cma.j.issn.1005-1015.2016.02.003
- VernacularTitle:认识糖尿病视网膜病变易感基因研究现状与挑战,提高糖尿病视网膜病变易感基因研究水平
- Author:
Ruifang SUI
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy/etiology;
Diabetic retinopathy/genetics;
Genes/genetics;
Editorial
- From:
Chinese Journal of Ocular Fundus Diseases
2016;32(2):122-125
- CountryChina
- Language:Chinese
-
Abstract:
It is clear that genetic background contributes to the development and progression of diabetic retinopathy (DR).However,the identification of susceptibility loci through candidate gene approaches,linkage disequilibrium analysis of case-control data and genome wide association study is still in its infancy and faces many challenges due to the complexity of the disease itself.China has rich resources of clinical samples.In order to facilitate elucidating the susceptibility genes of DR in China,we look forward multi-disciplinary,multi-regional collaboration studies integrating novel technologies,such as proteomics,metabolomics and next-generation sequencing to analyze gene-gene and gene-environment interaction factors comprehensively.
