Possibility of Zebrafish as New infection model for Leprosy.
- Author:
Jong Pill KIM
1
;
Hae Young CHOI
;
Sang Nae CHO
Author Information
1. Institute for Leprosy Research, Korean Hansen Welfare Association, Korea. dr_jpkim@hotmail.com
- Publication Type:Original Article
- Keywords:
infection model;
zebrafish;
Mycobacterium leprae
- MeSH:
Leprosy*;
Models, Animal;
Mycobacterium leprae;
Peritoneum;
Zebrafish*
- From:Korean Leprosy Bulletin
2006;39(1):37-48
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The zebrafish emerged as a new model of developmental research and infection. Recently zebrafish were used for various mycobacterial infection studies. In this study, we investigated a possibility of the zebrafish as an infection model of Mycobacterium leprae infection. We injected Mycobacterium leprae (10(5)/30microliter) to the peritoneum of zebrafish. After 4 weeks, we found two fish evident to the subsistence and multiplication of Mycobacterium leprae, among total 25 fish. This study thus demonstrates that zebrafish may become an animal model for M. leprae infection.
