Relationship between nocturnal hypoglycemia and cognitive function in aged type 2 diabetic patients
10.3760/cma.j.issn.1671-7368.2016.01.013
- VernacularTitle:老年2型糖尿病患者动态血糖监测下夜间低血糖与认知功能的关系
- Author:
Yuanyuan CHEN
;
Hua ZHANG
;
Gaozhong HUANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2,aged;
Nocturnal hypoglycemia;
Cognitive disorders;
Retrospective study
- From:
Chinese Journal of General Practitioners
2016;15(1):43-46
- CountryChina
- Language:Chinese
-
Abstract:
Two hundred and eleven aged patients with type 2 diabetes were enrolled in the study.Blood glucose levels were monitored with continuing glucose monitoring system (CGMS) for 3 days and the cognitive function was evaluated with Mini-Mental State Examination(MMSE) scale.The correlation between hypoglycemia(or nocturnal hypoglycemia) and MMSE scores was evaluated.CGMS recorded hypoglycemia in 47％ patients (100/211),82％ of whom (82/100) had nocturnal hypoglycemia.Patients with hypoglycemia had lower MMSE scores than those without hypoglycemia (25.1 ± 5.1 vs.26.8 ± 3.0,P ＜ 0.05).Furthermore,the incidence of hypoglycemia(or nocturnal hypoglycemia) was higher in patients with MMSE≤24 than that in patients with MMSE ＞ 24(P ＜0.05).The median of hypoglycemia maximal time and nocturnal hypoglycemia maximal time were longer in patients with MMSE ≤ 24 than those with MMSE ＞ 24 (P ＜ 0.05).Stepwise regression analysis showed that the total time and maximal time of hypoglycemia(or nocturnal hypoglycemia),age,and education level were the main factors influencing MMSE scores in aged type 2 diabetic patients(all P ＜0.05).
