Secondary autoimmune hemolytic anemia in patients with tuberculosis : a report of 4 cases

VernacularTitle:结核感染继发自身免疫性溶血性贫血四例临床分析
Author: Haiyan XIE ; Daobin ZHOU
Publication Type:Journal Article
Keywords: Tuberculosis; Anemia,hemolytic,autoimmune
From: Chinese Journal of General Practitioners 2015;14(12):956-959
CountryChina
Language:Chinese
Abstract: Medical charts of tuberculotic patients with secondary autoimmune hemolytic anemia (AIHA) admitted to Peking Union Medical College Hospital (PUMCH)from 2006 to 2015 were retrospectively reviewed.Four cases with complete information of laboratory tests,imaging findings and bone marrow results were included.Therapy regimens and outcomes of survival were followed by phone call if needed.Ages at diagnosis of AIHA were 58-80 years old,hemoglobin levels were 31-73 g/L,Coomb tests were negative in all cascs.Thcrapy of cortical steroid did not work,while anti-TB therapy (including isoniazid,rifampicin,ethambutol) significantly improved hemoglobin to normal level in three cases during six to nine months.One case died within one week,for progressive TB to central neurological system.As one of rarc complications of TB,AIHA may be fatal.Early diagnosis and appropriately anti-TB therapy is helpful for good outcomes.